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review article

Activation of aminocyclopropanes via radical intermediates

Wang, Ming-Ming
•
Nguyen, Tin V. T.
•
Waser, Jerome  
August 8, 2022
Chemical Society Reviews

Aminocyclopropanes are versatile building blocks for accessing high value-added nitrogen-containing products. To control ring-opening promoted by ring strain, the Lewis acid activation of donor-acceptor substituted systems is now well established. Over the last decade, alternative approaches have emerged proceeding via the formation of radical intermediates, alleviating the need for double activation of the cyclopropanes. This tutorial review summarizes key concepts and recent progress in ring-opening transformations of aminocyclopropanes via radical intermediates, divided into formal cycloadditions and 1,3-difunctionalizations.

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Type
review article
DOI
10.1039/d2cs00090c
Web of Science ID

WOS:000837423900001

Author(s)
Wang, Ming-Ming
Nguyen, Tin V. T.
Waser, Jerome  
Date Issued

2022-08-08

Publisher

Royal Society of Chemistry

Published in
Chemical Society Reviews
Volume

51

Start page

7344

End page

7357

Subjects

Chemistry, Multidisciplinary

•

Chemistry

•

3+2 annulation

•

n-cyclopropylanilines

•

histone demethylase

•

photoredox catalysis

•

hydrogen abstraction

•

mechanistic probes

•

amino-acids

•

ring

•

oxidation

•

cycloaddition

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCSO  
Available on Infoscience
August 29, 2022
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/190316
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