Activation of aminocyclopropanes via radical intermediates
Aminocyclopropanes are versatile building blocks for accessing high value-added nitrogen-containing products. To control ring-opening promoted by ring strain, the Lewis acid activation of donor-acceptor substituted systems is now well established. Over the last decade, alternative approaches have emerged proceeding via the formation of radical intermediates, alleviating the need for double activation of the cyclopropanes. This tutorial review summarizes key concepts and recent progress in ring-opening transformations of aminocyclopropanes via radical intermediates, divided into formal cycloadditions and 1,3-difunctionalizations.
CSR2022-7344GreenAccess1.pdf
preprint
openaccess
CC BY
1.97 MB
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a6aab4e66f4e8b1d7061d348bc80d3e7
CSR2022-7344GreenAccess.pdf
postprint
embargo
2023-08-08
CC BY
1.98 MB
Adobe PDF
a5dba8254a83400b5f00fd188e5ace17