Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability

Jalil, Antoine; Pilot, Thomas; Bourgeois, Thibaut; Laubriet, Aline; Li, Xiaoxu; Diedisheim, Marc; Deckert, Valérie; Magnani, Charlène; Le Guern, Naïg; de Barros, Jean-Paul Paı̈s; Nguyen, Maxime; Pallot, G; Vouilloz, Adrien; Proukhnitzky, Lil; Hermetet, François; Aires, Virginie; Lesniewska, Éric; Lagrost, Laurent; Auwerx, Johan; Le Goff, Wilfried; Venteclef, Nicolas; Steinmetz, Éric; Thomas, Charles; Masson, David

doi:10.1016/j.xcrm.2025.102131

research article

Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability

Jalil, Antoine

•

Pilot, Thomas

•

Bourgeois, Thibaut

May 2025

Cell Reports Medicine

Highlights • LPCAT3 and ELOVL5 coordinate PUFA metabolism in macrophages • Dual LPCAT3/ELOVL5 deletion increases membrane cholesterol-enriched domains • This alteration enhances macrophage sensitivity to cytotoxic oxysterols