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  4. Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability
 
research article

Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability

Jalil, Antoine
•
Pilot, Thomas
•
Bourgeois, Thibaut
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May 2025
Cell Reports Medicine

Highlights • LPCAT3 and ELOVL5 coordinate PUFA metabolism in macrophages • Dual LPCAT3/ELOVL5 deletion increases membrane cholesterol-enriched domains • This alteration enhances macrophage sensitivity to cytotoxic oxysterols

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Type
research article
DOI
10.1016/j.xcrm.2025.102131
Author(s)
Jalil, Antoine

Université de Bourgogne

Pilot, Thomas

Université de Bourgogne

Bourgeois, Thibaut

Université de Bourgogne

Laubriet, Aline
Li, Xiaoxu  

École Polytechnique Fédérale de Lausanne

Diedisheim, Marc

Institut Necker Enfants Malades

Deckert, Valérie

Université de Bourgogne

Magnani, Charlène

Université de Bourgogne

Le Guern, Naïg

Université de Bourgogne

de Barros, Jean-Paul Paı̈s

Inserm

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Date Issued

2025-05

Publisher

Elsevier BV

Published in
Cell Reports Medicine
Article Number

102131

Start page

102131

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LISP  
Available on Infoscience
May 13, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/250095
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