New efficient synthesis of long chain di- and tri-aminopolyols

The asymmetric synthesis of long chain di- and tri-amino polyols is reported. The developed methodology is based on the functionalization of 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives that allows the selective introduction of amine moieties on defined positions of polyketide fragments. The versatile strategy disclosed here requires few purification steps and may generate a large panel of stereoisomers.


Publié dans:
European Journal of Organic Chemistry, 17, 3903-3909
Année
2006
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 Notice créée le 2006-05-15, modifiée le 2019-12-05


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