New efficient synthesis of long chain di- and tri-aminopolyols

• Published in: European Journal of Organic Chemistry, num. 17, p. 3903-3909
• Publication date: 2006

The asymmetric synthesis of long chain di- and tri-amino polyols is reported. The developed methodology is based on the functionalization of 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives that allows the selective introduction of amine moieties on defined positions of polyketide fragments. The versatile strategy disclosed here requires few purification steps and may generate a large panel of stereoisomers.

Keywords: aminopolyols ; polyketides ; selective protection

Reference

• LGSA-ARTICLE-2006-006
• doi:10.1002/ejoc.200600276
• View record in Web of Science

Record created on 2006-05-15, modified on 2017-05-12