New efficient synthesis of long chain di- and tri-aminopolyols

The asymmetric synthesis of long chain di- and tri-amino polyols is reported. The developed methodology is based on the functionalization of 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives that allows the selective introduction of amine moieties on defined positions of polyketide fragments. The versatile strategy disclosed here requires few purification steps and may generate a large panel of stereoisomers.


Published in:
European Journal of Organic Chemistry, 17, 3903-3909
Year:
2006
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 Record created 2006-05-15, last modified 2018-12-03


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