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research article

Decoding bladder state from pudendal intraneural signals in pigs

Micera, Silvestro  
•
Giannotti A,
•
Lo Vecchio S,
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October 1, 2023
APL Bioengineering

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the literature, conditional, closed-loop stimulation paradigms have been shown to increase bladder capacity and voiding efficacy compared to continuous stimulation. Current limitations to the implementation of the closed-loop stimulation paradigm include the lack of robust and real-time decoding strategies for the bladder fullness state. We recorded intraneural pudendal nerve signals in five anesthetized pigs. Three bladder-filling states, corresponding to empty, full, and micturition, were decoded using the Random Forest classifier. The decoding algorithm showed a mean balanced accuracy above 86.67% among the three classes for all five animals. Our approach could represent an important step toward the implementation of an adaptive real-time closed-loop stimulation protocol for pudendal nerve modulation, paving the way for the design of an assisted-as-needed neuroprosthesis.

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APLBioeng-2023-bladder.pdf

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Publisher

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http://purl.org/coar/version/c_970fb48d4fbd8a85

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openaccess

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CC BY

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3.59 MB

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Adobe PDF

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12417673f5777a83bc485a14ae03655c

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