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research article

Decoding bladder state from pudendal intraneural signals in pigs

Micera, Silvestro  
•
Giannotti A,
•
Lo Vecchio S,
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October 1, 2023
APL Bioengineering

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the literature, conditional, closed-loop stimulation paradigms have been shown to increase bladder capacity and voiding efficacy compared to continuous stimulation. Current limitations to the implementation of the closed-loop stimulation paradigm include the lack of robust and real-time decoding strategies for the bladder fullness state. We recorded intraneural pudendal nerve signals in five anesthetized pigs. Three bladder-filling states, corresponding to empty, full, and micturition, were decoded using the Random Forest classifier. The decoding algorithm showed a mean balanced accuracy above 86.67% among the three classes for all five animals. Our approach could represent an important step toward the implementation of an adaptive real-time closed-loop stimulation protocol for pudendal nerve modulation, paving the way for the design of an assisted-as-needed neuroprosthesis.

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Type
research article
DOI
10.1063/5.0156484
Author(s)
Micera, Silvestro  
Giannotti A,
Lo Vecchio S,
Musco S.
Pollina L.  
Vallone F.
Strauss I.
Paggi, Valentina Marie  
Bernini F.
Gabisonia K.
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Date Issued

2023-10-01

Published in
APL Bioengineering
Volume

7

Issue

4

Article Number

046101

Subjects

Machine learning

•

Signal processing

•

Diseases and conditions

•

Neural engineering

•

Neuroprosthetics

•

Animal model

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSBI  
TNE  
FunderGrant Number

Other government funding

PR19-CR-P2

Other foundations

Bertarelli Foundation

Available on Infoscience
October 23, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/201883
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