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  4. Resolution and penetration depth of reflection-mode time-domain near infrared optical tomography using a ToF SPAD camera
 
research article

Resolution and penetration depth of reflection-mode time-domain near infrared optical tomography using a ToF SPAD camera

Jiang, Jingjing
•
Ackermann, Meret
•
Russomanno, Emanuele
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December 1, 2022
Biomedical Optics Express

In a turbid medium such as biological tissue, near-infrared optical tomography (NIROT) can image the oxygenation, a highly relevant clinical parameter. To be an efficient diagnostic tool, NIROT has to have high spatial resolution and depth sensitivity, fast acquisition time, and be easy to use. Since many tissues cannot be penetrated by near-infrared light, such tissue needs to be measured in reflection mode, i.e., where light emission and detection components are placed on the same side. Thanks to the recent advance in single-photon avalanche diode (SPAD) array technology, we have developed a compact reflection-mode time-domain (TD) NIROT system with a large number of channels, which is expected to substantially increase the resolution and depth sensitivity of the oxygenation images. The aim was to test this experimentally for our SPAD camera-empowered TD NIROT system. Experiments with one and two inclusions, i.e., optically dense spheres of 5mm radius, immersed in turbid liquid were conducted. The inclusions were placed at depths from 10mm to 30mm and moved across the field-of-view. In the two-inclusion experiment, two identical spheres were placed at a lateral distance of 8mm. We also compared short exposure times of 1s, suitable for dynamic processes, with a long exposure of 100s. Additionally, we imaged complex geometries inside the turbid medium, which represented structural elements of a biological object. The quality of the reconstructed images was quantified by the root mean squared error (RMSE), peak signal-to-noise ratio (PSNR), and dice similarity. The two small spheres were successfully resolved up to a depth of 30mm. We demonstrated robust image reconstruction even at 1s exposure. Furthermore, the complex geometries were also successfully reconstructed. The results demonstrated a groundbreaking level of enhanced performance of the NIROT system based on a SPAD camera.

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Type
research article
DOI
10.1364/BOE.470985
Web of Science ID

WOS:000917262200038

Author(s)
Jiang, Jingjing
Ackermann, Meret
Russomanno, Emanuele
Mata, Aldo di Costanzo
Charbon, Edoardo  
Wolf, Martin
Kalyanov, Alexander
Date Issued

2022-12-01

Publisher

Optica Publishing Group

Published in
Biomedical Optics Express
Volume

13

Issue

12

Start page

6711

End page

6723

Subjects

Biochemical Research Methods

•

Optics

•

Radiology, Nuclear Medicine & Medical Imaging

•

Biochemistry & Molecular Biology

•

measurement density-functions

•

reconstruction

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
AQUA  
Available on Infoscience
February 27, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/195223
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