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  4. Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria
 
research article

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Pegolotti, Luca  
•
Dede, Luca  
•
Quarteroni, Alfio  
January 1, 2019
Computer Methods In Applied Mechanics And Engineering

We consider Isogeometric Analysis (IGA) for the numerical solution of the electrophysiology of the atria, which in this work is modeled by means of the bidomain equations on thin surfaces. First, we consider the bidomain equations coupled with the Roger-McCulloch ionic model on simple slabs. Here, our goal is to evaluate the effects of the spatial discretization by IGA and the use of different B-spline basis functions on the accuracy of the approximation, in particular regarding the accuracy of the front velocity and the dispersion error. Specifically, we consider basis functions with high polynomial degree, p, and global high order continuity, Cp-1, in the computational domain: our results show that the use of such basis functions is beneficial to the accurate approximation of the solution. Then, we consider a realistic application of the bidomain equations coupled with the Courtemanche-Ramirez-Nattel ionic model on the two human atria, which are represented by means of two NURBS surfaces. (C) 2018 Elsevier B.V. All rights reserved.

  • Details
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Type
research article
DOI
10.1016/j.cma.2018.08.032
Web of Science ID

WOS:000447411100004

Author(s)
Pegolotti, Luca  
Dede, Luca  
Quarteroni, Alfio  
Date Issued

2019-01-01

Publisher

ELSEVIER SCIENCE SA

Published in
Computer Methods In Applied Mechanics And Engineering
Volume

343

Start page

52

End page

73

Subjects

Engineering, Multidisciplinary

•

Mathematics, Interdisciplinary Applications

•

Mechanics

•

Engineering

•

Mathematics

•

isogeometric analysis

•

cardiac electrophysiology

•

bidomain equations

•

partial-differential-equations

•

action-potential propagation

•

monodomain models

•

surfaces

•

electromechanics

•

discretization

•

repolarization

•

refinement

•

generation

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
Available on Infoscience
January 23, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/153936
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