Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model
Iinuma, Seiichi; Wagnieres, Georges; Schomacker, Kevin T.; Bamberg, Mike; Hasan, Tayyaba
1995

Abstract

Oxygen dependent phototoxicity was investigated in vivo in an orthotopic rat bladder tumor model. Two photosensitizers, benzoporphyrin derivative monoacid ring A and 5-aminolevulinic acid-induced protoporphyrin IX were studied. For a given cumulative light dose of 30 J/cm 2, enhanced tumor destruction was obtained for both photosensitizers by either using a low fluence rate or fractionated light delivery mode. These observations may be attributed to rapid local oxygen consumption during photochemical reactions.

Details

Title Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model
Author(s) Iinuma, Seiichi ; Wagnieres, Georges ; Schomacker, Kevin T. ; Bamberg, Mike ; Hasan, Tayyaba
Published in Proceedings of SPIE - The International Society for Optical Engineering
Volume 2392
Pages 136-140
Date 1995
DOI https://doi.org/10.1117/12.208182
Laboratories LPAS
Record Appears in Scientific production and competences > ENAC - School of Architecture, Civil and Environmental Engineering > ENAC Archives > LPAS - Air and Soil Pollution Laboratory
Conference Papers
Work produced at EPFL
Published
Record creation date 2014-02-06

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