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conference paper
Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model
1995
Proceedings of SPIE - The International Society for Optical Engineering
Oxygen dependent phototoxicity was investigated in vivo in an orthotopic rat bladder tumor model. Two photosensitizers, benzoporphyrin derivative monoacid ring A and 5-aminolevulinic acid-induced protoporphyrin IX were studied. For a given cumulative light dose of 30 J/cm 2, enhanced tumor destruction was obtained for both photosensitizers by either using a low fluence rate or fractionated light delivery mode. These observations may be attributed to rapid local oxygen consumption during photochemical reactions.
Type
conference paper
Authors
Publication date
1995
Published in
Proceedings of SPIE - The International Society for Optical Engineering
Volume
2392
Start page
136
End page
140
Peer reviewed
NON-REVIEWED
EPFL units
Available on Infoscience
February 6, 2014
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