Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin
 
research article

Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Alonso-Sarduy, Livan  
•
Longo, Giovanni  
•
Dietler, Giovanni  
Show more
2013
Nano Letters

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.

  • Details
  • Metrics
Type
research article
DOI
10.1021/nl403361f
Web of Science ID

WOS:000327111700107

Author(s)
Alonso-Sarduy, Livan  
Longo, Giovanni  
Dietler, Giovanni  
Kasas, Sandor  
Date Issued

2013

Publisher

American Chemical Society

Published in
Nano Letters
Volume

13

Issue

11

Start page

5679

End page

5684

Subjects

DNA intercalating agents

•

daunorubicin

•

AFM

•

linking number

•

time-lapse imaging

•

drug development

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LPMV  
Available on Infoscience
January 9, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/99344
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés