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  4. Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin
 
research article

Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Alonso-Sarduy, Livan  
•
Longo, Giovanni  
•
Dietler, Giovanni  
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2013
Nano Letters

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.

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