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research article
Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion
Activated: The title reaction proceeds efficiently with 1 mol % of palladium and gives tetrahydroquinolines in excellent enantioselectivities (see scheme). The enantiodiscriminating concerted metalation-deprotonation step occurs via a rare seven-membered palladacycle. The cyclopropyl-substituted tetrahydroquinolines can be regioselectively and enantiospecifically reduced to chiral tetrahydrobenzoazepines. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Type
research article
Web of Science ID
WOS:000304044900025
Authors
Publication date
2012
Publisher
Published in
Volume
51
Issue
21
Start page
5170
End page
5174
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
May 24, 2012
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