Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion
Activated: The title reaction proceeds efficiently with 1 mol % of palladium and gives tetrahydroquinolines in excellent enantioselectivities (see scheme). The enantiodiscriminating concerted metalation-deprotonation step occurs via a rare seven-membered palladacycle. The cyclopropyl-substituted tetrahydroquinolines can be regioselectively and enantiospecifically reduced to chiral tetrahydrobenzoazepines. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Yao, B., Wang, Q., & Zhu, J. (2012). Palladium(II)-Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion. Angewandte Chemie International Edition, 51(21), 5170–5174. https://doi.org/10.1002/anie.201201640
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WOS:000304044900025
2012
51
21
5170
5174
REVIEWED
EPFL