Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
Viertl, David; Delaloye, Angelika Bischof; Lanz, Bernard; Poitry-Yamate, Carole; Gruetter, Rolf; Mlynarik, Vladimir; Ametamey, Simon M.; Ross, Tobias L.; Lehr, Hans-Anton; Andre, Pierre-Alain; Perillo-Adamer, Florence; Kosinski, Marek; Dupertuis, Yves M.; Buchegger, Franz
2011

Files

Abstract

3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [F-18]FLT in tumor xenografts.

Details

Title Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
Author(s) Viertl, David ; Delaloye, Angelika Bischof ; Lanz, Bernard ; Poitry-Yamate, Carole ; Gruetter, Rolf ; Mlynarik, Vladimir ; Ametamey, Simon M. ; Ross, Tobias L. ; Lehr, Hans-Anton ; Andre, Pierre-Alain ; Perillo-Adamer, Florence ; Kosinski, Marek ; Dupertuis, Yves M. ; Buchegger, Franz
Published in Molecular Imaging And Biology
Volume 13
Pages 321-331
Date 2011
Publisher Elsevier
ISSN 1536-1632
Keywords
DOI https://doi.org/10.1007/s11307-010-0368-z
Other identifier(s) View record in Web of Science
Laboratories LIFMET
CIBM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > IPHYS - Institute of Physics > LIFMET - Laboratory of functional and metabolic imaging
Scientific production and competences > SB - School of Basic Sciences > CIBM - Biomedical Imaging Research Center
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2011-12-16

Actions

Preview