research article
Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [F-18]FLT in tumor xenografts.
Type
research article
Web of Science ID
WOS:000288177700016
Author(s)
Viertl, David
Delaloye, Angelika Bischof
Ametamey, Simon M.
Ross, Tobias L.
Lehr, Hans-Anton
Andre, Pierre-Alain
Date Issued
2011
Publisher
Published in
Volume
13
Start page
321
End page
331
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
Available on Infoscience
December 16, 2011
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