research article
Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline
2001
Pictet–Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated. Syntheses and functional group transformations of 1,1-disubstituted tetrahydroisoquinoline are reported.
Type
research article
Author(s)
Date Issued
2001
Publisher
Published in
Volume
42
Issue
27
Start page
4503
End page
4506
Editorial or Peer reviewed
NON-REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
November 25, 2010
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