Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline

Pictet–Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated. Syntheses and functional group transformations of 1,1-disubstituted tetrahydroisoquinoline are reported.


Published in:
Tetrahedron Letters, 42, 27, 4503-4506
Year:
2001
Publisher:
Elsevier
ISSN:
00404039
Keywords:
Laboratories:




 Record created 2010-11-25, last modified 2018-04-07


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