Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline

• Published in: Tetrahedron Letters (ISSN: 00404039), vol. 42, num. 27, p. 4503-4506
• Elsevier, 2001

Pictet-Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated. © 2001 Elsevier Science Ltd.

Reference

• EPFL-ARTICLE-158258
• doi:10.1016/S0040-4039(01)00776-6

Record created on 2010-11-25, modified on 2017-05-12