Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline

Bois-Choussy, M.; Cadet, S.; De Paolis, M.; Zhu, J.

doi:10.1016/S0040-4039(01)00776-6

research article

Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline

Bois-Choussy, M.

•

Cadet, S.

•

De Paolis, M.

2001

Tetrahedron Letters

Pictet–Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated. Syntheses and functional group transformations of 1,1-disubstituted tetrahydroisoquinoline are reported.