Rational Design of an Organometallic Glutathione Transferase Inhibitor
Double trouble: A hybrid org.-inorg. (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the org. moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophys. and biochem. methods.
Record created on 2009-06-11, modified on 2016-08-08