Rational Design of an Organometallic Glutathione Transferase Inhibitor

Double trouble: A hybrid org.-inorg. (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the org. moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophys. and biochem. methods.


Published in:
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, 48, 21, 3854-3857
Year:
2009
Keywords:
Laboratories:




 Record created 2009-06-11, last modified 2018-03-17


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