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research article
Rational Design of an Organometallic Glutathione Transferase Inhibitor
Double trouble: A hybrid org.-inorg. (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the org. moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophys. and biochem. methods.
Type
research article
Web of Science ID
WOS:000266275700028
Authors
•
Parker, Lorien J.
•
De Luca, Anastasia
•
Juillerat-Jeanneret, Lucienne
•
Morton, Craig J.
•
Lo Bello, Mario
•
Parker, Michael W.
•
Publication date
2009
Published in
Volume
48
Issue
21
Start page
3854
End page
3857
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 11, 2009
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