The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.


Published in:
Annals of the New York Academy of Sciences, 973, 26-30
Year:
2002
ISSN:
0077-8923
Other identifiers:
Laboratories:




 Record created 2009-04-02, last modified 2018-03-18


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