The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion
Fournier, Thierry; Pavan, Laetitia; Tarrade, Anne; Schoonjans, Kristina; Auwerx, Johan; Rochette-Egly, Cecile; Evain-Brion, Daniele
2002

Abstract

PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.

Details

Title The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion
Author(s) Fournier, Thierry ; Pavan, Laetitia ; Tarrade, Anne ; Schoonjans, Kristina ; Auwerx, Johan ; Rochette-Egly, Cecile ; Evain-Brion, Daniele
Published in Annals of the New York Academy of Sciences
Volume 973
Pages 26-30
Date 2002
ISSN 0077-8923
DOI https://doi.org/10.1111/j.1749-6632.2002.tb04601.x
Other identifier(s) View record in PubMed
Laboratories UPSCHOONJANS
NCEM
Record Appears in Scientific production and competences > SV - School of Life Sciences > IBI-SV - Interfaculty Institute of Bioengineering > NCEM - Nestlé Chair in Energy Metabolism
Peer-reviewed publications
Work outside EPFL
Published
Reviews
Record creation date 2009-04-02

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