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review article
The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion
PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.
Type
review article
PubMed ID
12485829
Authors
Fournier, Thierry
•
Pavan, Laetitia
•
Tarrade, Anne
•
•
•
Rochette-Egly, Cecile
•
Evain-Brion, Daniele
Publication date
2002
Published in
Volume
973
Start page
26
End page
30
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 2, 2009
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