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  4. Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat
 
research article

Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat

Markram, H  
•
Segal, M
1990
Neurobiology of aging

A monoclonal antibody to the nerve growth factor receptor (NGFR) (IgG 192) was used to visualize differences in immunohistochemical labeling of young (10 months) and old (35 months) rats. Three parameters were analyzed; cell counts, immunoreactive cross-sectional surface area (SA) and optical density (OD) of labeled cells. Large reductions in all three parameters were recorded in the medial septum (MS). Both OD and immunoreactive SA were reduced in the VDB, while only OD was reduced in the HDB. This observation confirms that NGFR labeling is reduced in the aged rat septum and adds that the loss of labeling is differential, with greater deficits in the MS-VDB complex than in the HDB.

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Type
research article
DOI
10.1016/0197-4580(90)90017-T
PubMed ID

2166241

Author(s)
Markram, H  
Segal, M
Date Issued

1990

Published in
Neurobiology of aging
Volume

11

Issue

4

Start page

481

End page

484

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNMC  
Available on Infoscience
January 28, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88313
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