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  4. Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs
 
research article

Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs

Markram, H.  
•
Lübke, J.
•
Frotscher, M.
Show more
1997
Science

Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.

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Type
research article
DOI
10.1126/science.275.5297.213
PubMed ID

8985014

Author(s)
Markram, H.  
Lübke, J.
Frotscher, M.
Sakmann, B.
Date Issued

1997

Publisher

American Association for the Advancement of Science

Published in
Science
Volume

275

Issue

5297

Start page

213

End page

215

Subjects

Synaptic Transmission

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNMC  
Available on Infoscience
January 28, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88301
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