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research article
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols
New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-Dribitol (13, IC50 similar to 2 mu M) and its C-18-analogues (IC50 < 10 mu M) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC50 similar to 8 mu M) growth of JURKAT cells. (C) 2011 Published by Elsevier Ltd.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000297860100044
Authors
Bello, Claudia
•
Dal Bello, Giovanna
•
Cea, Michele
•
Nahimana, Aimable
•
Aubry, Dominique
•
Garuti, Anna
•
Motta, Giulia
•
Moran, Eva
•
Fruscione, Floriana
•
Pronzato, Paolo
Publication date
2011
Published in
Volume
19
Start page
7720
End page
7727
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 12, 2012