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research article
Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives
2010
3,6-Anhydro-1-(aryl or alkylamino)-1-deoxy-D-sorbitol derivatives have been prepared in four steps from isosorbide, a by-product from the starch industry. The inhibitory activities of these new compounds have been evaluated towards 13 glycosidases. A first lead-compound was identified, which inhibited beta-N-acetylglucosaminidase from bovine kidney (82% inhibition at 1 mM). (C) 2009 Elsevier Inc. All rights reserved.
Type
research article
Web of Science ID
WOS:000277377600007
Authors
Publication date
2010
Published in
Volume
38
Start page
43
End page
47
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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