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research article
Concise Total Synthesis of (±)-Marcfortine B
The marcfortine alkaloids are complex indolic secondary metabolites isolated from various Penicillium sp. and are potent anthelmintic agents. Herein, we report the first total synthesis of marcfortine B (I). The key features of our synthesis are the use of the carboxylative TMM-cycloaddn. to construct the central spirocyclic cyclopentane core and an intramol. Michael-addn. and radical cyclization to access its strained bicyclo[2.2.2]diazaoctane ring system.
Type
research article
Authors
Publication date
2007
Publisher
Published in
Volume
129
Start page
3086
End page
3087
Note
CAPLUS AN 2007:196970(Journal)
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 17, 2011
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