A five-component synthesis of hexasubstituted benzenes
A one-pot, 5-component, domino process was used to prep. 7 hexasubstituted benzenes, e.g., I, in 32-67% yield. The 5 components for I were BuNH2, heptanal, isocyanide II, PhC==CCO2C6F5, and N-phenylmaleimide. The process creates 7 chem. bonds and delivers 5 elements of diversity into the compact polyheterocycle. [on SciFinder (R)]
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Janvier, P., Bienayme, H., & Zhu, J. (2002). A five-component synthesis of hexasubstituted benzenes. Angewandte Chemie International Edition, 41(22), 4291–4294. https://doi.org/10.1002/1521-3773(20021115)41:22<4291::AID-ANIE4291>3.0.CO;2-D
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2002
41
22
4291
4294
CAN 138:353915
28-13
Heterocyclic Compounds (More Than One Hetero Atom)
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
104-53-0 (3-Phenylpropionaldehyde); 108-31-6 (Maleic anhydride); 109-73-9 (Butylamine); 111-71-7 (Heptanal); 120-20-7; 130-15-4 (1,4-Naphthalenedione); 459-57-4 (4-Fluorobenzaldehyde); 762-42-5 (Dimethyl acetylenedicarboxylate); 941-69-5 (N-Phenylmaleimide); 2780-89-4 (Methyl 6-aminocaproate); 7299-58-3; 85059-48-9; 380374-35-6; 411222-61-2; 518999-19-4 Role: RCT (Reactant), RACT (Reactant or reagent) (one-pot five-component synthesis of hexasubstituted benzenes); 518999-10-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (one-pot five-component synthesis of hexasubstituted benzenes); 518999-12-7P; 518999-14-9P; 518999-16-1P; 518999-21-8P; 518999-23-0P; 518999-25-2P; 518999-27-4P; 518999-29-6P; 518999-31-0P Role: SPN (Synthetic preparation), PREP (Preparation) (one-pot five-component synthesis of hexasubstituted benzenes)
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