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research article
Nonenzymic polycyclisation of analogues of oxidosqualene with a preformed C-ring
Some nonenzymic epoxide-initiated polyolefin cyclisations are reported. The presented molecules are partially constrained analogues of (3S)-oxidosqualene, the natural substrate to many important cyclase enzymes. These model compounds feature a preformed C-ring with built-in stereochemical information. The experimental results allow for an instructive comparison with the enzymic processes, particularly those of the cyclases in steroid biosynthesis (i.e. lanosterol synthase).
Type
research article
Web of Science ID
WOS:000255927800008
Authors
Publication date
2008
Published in
Volume
6
Start page
1918
End page
1925
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
January 11, 2010
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