research article
Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD
- The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors. 2. Doses of d-LSD ranging from 0.25 to 2.5 mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour. 3. In contrast, when similar doses of d-LSD were injected 10 min before apomorphine (5 mg/kg), a constant potentiation of the apomorphine-induced climbing was observed. 4. Subsequent experiments performed with a neuroleptic (haloperidol) or a serotonin precursor (5-OH-tryptophan) compared to those of d-LSD with and without apomorphine would indicate that d-LSD alone displays typical serotoninergic syndrome (including inhibition of the climbing), whereas in the presence of apomorphine, an interaction at presynaptic receptors may possibly modulate dopaminergic activity.
Type
research article
PubMed ID
401002
Author(s)
Date Issued
1979
Published in
Volume
3
Issue
5-6
Start page
503
End page
11
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
January 8, 2010
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