Improved microfluidic transcriptome based screening methods
The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so called old mRNA and such differences compared to control cell assays. The invention is applicable for screening in particular candidate ligand molecules such as antibodies for an effect on target cells, and thereby provides new strategies for the identification of therapeutically active compounds.
83151774
Alternative title(s) : (de) Verbesserte screening-verfahren basierend auf mikrofluidischem transkriptom (fr) Procédés de criblage à base de transcriptomes microfluidiques améliorés
TTO:6.2363
Patent number | Country code | Kind code | Date issued |
WO2024047028 | WO | A1 | 2024-03-07 |
EP4332234 | EP | A1 | 2024-03-06 |