The Serviceability Limit States (SLS) of reinforced concrete structures, where cracking and deflection limits are verified in the design process, are directly related to time-dependent properties of concrete. In this study, the effects of creep and shrinkage of concrete, implemented in a Finite Element Model for Non-Linear Analysis, are in-deeply investigated for reinforced concrete flat slabs at SLS and used as basis for the development of an analytical framework. In particular, the paper focuses on: (i) the description of the FE model, (ii) the comparison between the numerical and experimental results of some reinforced concrete (RC) flat slab tests from literature characterized by different mechanical properties, span-to-depth ratios, boundary conditions and loading histories and (iii) the development of an analytical framework for the evaluation of long term-term deflections and crack openings in hogging regions of flat slabs near columns. Based on the findings, useful insights for the evaluation of the long term-term deflections and crack opening in the context of Serviceability Limit States are provided for practical purposes.