Novel cathepsin inhibitors
The present invention relates to a cathepsin inhibitor comprising or consisting of Formula (I) (X1)(X2)(X3)(X4)(Y)(X5)(X6)(X7) wherein (X1) is an amino acid selected from K, L, F and M; (X2) is an amino acid selected from L, A, D, E, F, G, H, I, K, M, N, S, W, Y, Q and R; (X3) is an amino acid selected from R, A and L; (X4) is an amino acid selected from M, I, K, V and Y; (X5) is an amino acid selected from P, A, I, L, V, W and Y; (X6) is an amino acid selected from K, A, E, F, G, I, L, M, N, Q, S, T, V, W, Y and Q; (X7) is an amino acid selected from D, A, E, F, G, I, L, M, N, P, T, V, W, Y, Q and R; and (Y) is a Michael acceptor.
77750041
Alternative title(s) : (de) Neue cathepsinhemmer (fr) Nouveaux inhibiteurs de la cathepsine
TTO:6.2183
Patent number | Country code | Kind code | Date issued |
EP4387981 | EP | A1 | 2024-06-26 |
CN118139871 | CN | A | 2024-06-04 |
AU2022331815 | AU | A1 | 2024-03-07 |
CA3229302 | CA | A1 | 2023-02-23 |
WO2023021190 | WO | A1 | 2023-02-23 |
EP4137503 | EP | A1 | 2023-02-22 |