With the increasing strength and frequency of climate change events, the urgency to mitigate climate change impact is ever so important. Canada reported his Nationally Determined Contribution (NDC) and submitted its ambition to reduce his Greenhouse Gas (GHG) emissions by 40-45% by 2030 compared to 2005 and reach net-zero emissions by 2050. Interest for energy system modelling has been increasing for planning future energy systems, as a result of growing concern for sustainable development and transition towards renewable energies. Nevertheless, planning a decarbonization of energy system can potentially lead to environmental burden shifting, and can increase impacts on other environmental impacts such as ecosystem quality or human health. Thus, this project aims towards integrating Life Cycle Analysis (LCA) and more specifically Life Cycle Impact Assessment (LCIA) within Energy Systems Modelling, in order to minimize not only climate change impacts, but human health and ecosystem quality. In addition, a dual spatial resolution was integrated in the model in order to increase data precision and computational efficiency. The results show that a low-carbon energy system, based on the optimization of GHG emissions allows to greatly reduce all the environmental impacts under analysis, compared to an all economic- based energy system, but a multi-objective optimization allows to simultaneously reduce impacts on ecosystem quality and human health, while reducing GHG emissions and keeping good economical and technical performances. The results also show that it is theoretically possible for Canada to keep on track with their emission reduction ambition by 2030, by deploying more renewable energies. This project does not allow assessing Canada’s potential to reach net-zero emissions, as environmental impacts from carbon capture technologies are still to be characterized and integrated in the model.