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  4. Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?
 
research article

Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?

Abriata, Luciano A.  
•
Dal Peraro, Matteo  
May 26, 2020
Journal Of Chemical Information And Modeling

Protein dynamics is undoubtedly a pervasive ingredient in all biological functions. However, structural biology has been strongly driven by a static-centered view of protein architecture. We argue that the recent advances of cryo-electron microscopy (EM) have the potential to more broadly explore the conformational landscapes of protein complexes and therefore will enhance our ability to predict the diverse conformations of tertiary and quaternary protein structures that are functionally relevant in physiological conditions.

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Type
research article
DOI
10.1021/acs.jcim.0c00177
Web of Science ID

WOS:000537653400008

Author(s)
Abriata, Luciano A.  
Dal Peraro, Matteo  
Date Issued

2020-05-26

Publisher

AMER CHEMICAL SOC

Published in
Journal Of Chemical Information And Modeling
Volume

60

Issue

5

Start page

2443

End page

2447

Subjects

Chemistry, Medicinal

•

Chemistry, Multidisciplinary

•

Computer Science, Information Systems

•

Computer Science, Interdisciplinary Applications

•

Pharmacology & Pharmacy

•

Chemistry

•

Computer Science

•

contact predictions

•

coevolution

•

dynamics

•

ensemble

•

sequence

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPDALPE  
Available on Infoscience
June 18, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/169396
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