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  4. An Interactive Gameplay to Crowdsource Multiple Sequence Alignment of Genome Sequences: Genenigma
 
conference paper

An Interactive Gameplay to Crowdsource Multiple Sequence Alignment of Genome Sequences: Genenigma

Meedeniya, D. A.
•
Rukshan, S. A. P. A.
•
Welivita, A.  
January 1, 2019
2019 9Th International Conference On Bioscience, Biochemistry And Bioinformatics (Icbbb 2019)
9th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB)

Comparative genomics is a field of research that compares genomes of different organisms to identify common patterns. It is a powerful method used to identify the genetic diseases that cause mutations. Multiple Sequence Alignment (MSA) is an intermediate step in comparative genomics analysis that aligns three or more biological sequences of similar length. MSA is an NP-hard problem for which no efficient algorithm exists to perform this in a reasonable amount of time. However, humans across evolution have developed special intuition to identify visual patterns in short periods of time. Hence, a citizen science approach can be devised to solve the MSA problem by transforming it into a human computing game on creating visually similar patterns. In this paper, we introduce the mobile game "Genenigma", which harnesses the human computing capability to align multiple sequences of genomes and use the results to help geneticists to understand the genetic code. The usability and performance scores of "Genenigma" predicts a larger user base than existing mobile games built for this purpose.

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Type
conference paper
DOI
10.1145/3314367.3314374
Web of Science ID

WOS:000473541100006

Author(s)
Meedeniya, D. A.
Rukshan, S. A. P. A.
Welivita, A.  
Date Issued

2019-01-01

Publisher

ASSOC COMPUTING MACHINERY

Publisher place

New York

Published in
2019 9Th International Conference On Bioscience, Biochemistry And Bioinformatics (Icbbb 2019)
ISBN of the book

978-1-4503-6654-0

Start page

28

End page

35

Subjects

comparative genomics

•

multiple sequence alignment

•

citizen science

•

crowdsourcing

•

gamification

•

genenigma application

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPSALATHE1  
Event nameEvent placeEvent date
9th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB)

Singapore, SINGAPORE

Jan 07-09, 2019

Available on Infoscience
July 17, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/159160
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