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  4. The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila
 
research article

The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila

Yanagawa, Aya
•
Neyen, Claudine  
•
Lemaitre, Bruno  
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2017
Plos One

Behavioral resistance protects insects from microbial infection. However, signals inducing insect hygiene behavior are still relatively unexplored. Our previous study demonstrated that olfactory signals from microbes enhance insect hygiene behavior, and gustatory signals even induce the behavior. In this paper, we postulated a cross-talk between behavioral resistance and innate immunity. To examine this hypothesis, we employed a previously validated behavioral test to examine the function of taste signals in inducing a grooming reflex in decapitated flies. Microbes, which activate different pattern recognition systems upstream of immune pathways, were applied to see if there was any correlation between microbial perception and grooming reflex. To narrow down candidate elicitors, the grooming induction tests were conducted with highly purified bacterial components. Lastly, the role of DAP-type peptidoglycan in grooming induction was confirmed. Our results demonstrate that cleaning behavior can be triggered through recognition of DAP-type PGN by its receptor PGRP-LC.

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Type
research article
DOI
10.1371/journal.pone.0185370
Web of Science ID

WOS:000414769900007

Author(s)
Yanagawa, Aya
Neyen, Claudine  
Lemaitre, Bruno  
Marion-Poll, Frederic
Date Issued

2017

Publisher

Public Library of Science

Published in
Plos One
Volume

12

Issue

11

Article Number

e0185370

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPLEM  
Available on Infoscience
December 4, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/142576
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