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review article

Pore-forming toxins: ancient, but never really out of fashion

Dal Peraro, Matteo  
•
Van Der Goot, F. Gisou
2016
Nature Reviews Microbiology

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and have long fascinated structural biologists, microbiologists and immunologists. Interestingly, pore-forming proteins with remarkably similar structures to PFTs are found in vertebrates and constitute part of their immune system. Recently, structural studies of several PFTs have provided important mechanistic insights into the metamorphosis of PFTs from soluble inactive monomers to cytolytic transmembrane assemblies. In this Review, we discuss the diverse pore architectures and membrane insertion mechanisms that have been revealed by these studies, and we consider how these features contribute to binding specificity for different membrane targets. Finally, we explore the potential of these structural insights to enable the development of novel therapeutic strategies that would prevent both the establishment of bacterial resistance and an excessive immune response.

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Type
review article
DOI
10.1038/nrmicro.2015.3
Web of Science ID

WOS:000369219400008

Author(s)
Dal Peraro, Matteo  
Van Der Goot, F. Gisou
Date Issued

2016

Publisher

Nature Publishing Group

Published in
Nature Reviews Microbiology
Volume

14

Issue

2

Start page

77

End page

92

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPDALPE  
Available on Infoscience
April 1, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/125419
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