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research article
Sulfonamide and Tertiary Amine as Nucleophiles in Pd(II)-Catalyzed Diamination of Alkynes: Synthesis of Tetracyclic Indolobenzothiazine S,S‑Dioxides
2015
Pd(II)-catalyzed oxidative double cyclization of the 1,2-diarylethynes bearing an N-methyl-N-(2-methoxycarbonyl)ethylamino and an aminosulfonyl group afforded indolobenzothiazine S,S-dioxides in good to excellent yields. The 2-(methoxycarbonyl)ethyl group attached to the indolyl nitrogen is readily removed under basic conditions (DBU, DMF, 120 °C) to provide the corresponding tetracycles with a free indolyl nitrogen in excellent yields.
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Type
research article
Web of Science ID
WOS:000364434900028
Authors
Publication date
2015
Publisher
Published in
Volume
17
Issue
21
Start page
5256
End page
5259
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 11, 2015