NIS-Assisted Aza-Friedel-Crafts Reaction with α-Carbamoysulfides as Precursors of
A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel–Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from a-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
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George, N., Bekkaye, M., Alix, A., Zhu, J., & Masson, G. (2014). NIS-Assisted Aza-Friedel-Crafts Reaction with α-Carbamoysulfides as Precursors of. Chemistry - A European Journal, 20(13), 3621–3625. https://doi.org/10.1002/chem.201400117
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WOS:000332757100011
2014
20
13
3621
3625
REVIEWED
EPFL