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  4. Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilines
 
research article

Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilines

Brand, Jonathan P.  
•
Waser, Jerome  
2012
Synthesis-Stuttgart

An efficient procedure was developed for the synthesis of 1-[(triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one on a 100-mmol (36-g) scale. The benziodoxolone can be used for the gold-catalyzed direct alkynylation of indole, 2-hexylthiophene, or N,N-dibenzylaniline on a 5- to 10-mmol scale.

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Type
research article
DOI
10.1055/s-0031-1290589
Web of Science ID

WOS:000303104400003

Author(s)
Brand, Jonathan P.  
Waser, Jerome  
Date Issued

2012

Published in
Synthesis-Stuttgart
Volume

44

Start page

1155

End page

1158

Subjects

alkynes

•

arenes

•

catalysis

•

heterocycles

•

iodine

•

Hypervalent Iodine

•

Heterocycles

•

Gold

•

Chemistry

•

Reagent

•

Ebx

•

Electrophilic Alkynylation

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCSO  
Available on Infoscience
May 18, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/80548
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