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research article

Objective Morphological Classification of Neocortical Pyramidal Cells

Kanari, Lida  
•
Ramaswamy, Srikanth  
•
Shi, Ying  
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April 1, 2019
Cerebral Cortex

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies. Even for neurons that are visually distinguishable, there is no common ground to consistently define morphological types. The objective classification of PCs can be achieved with methods from algebraic topology, and the dendritic arborization is sufficient for the reliable identification of distinct types of cortical PCs. Therefore, we objectively identify 17 types of PCs in the rat somatosensory cortex. In addition, we provide a solution to the challenging problem of whether 2 similar neurons belong to different types or to a continuum of the same type. Our topological classification does not require expert input, is stable, and helps settle the long-standing debate on whether cell-types are discrete or continuous morphological variations of each other.

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Type
research article
DOI
10.1093/cercor/bhy339
Web of Science ID

WOS:000482180900034

Author(s)
Kanari, Lida  
Ramaswamy, Srikanth  
Shi, Ying  
Morand, Sebastien
Meystre, Julie  
Perin, Rodrigo  
Abdellah, Marwan  
Wang, Yun
Hess, Kathryn  
Markram, Henry  
Date Issued

2019-04-01

Publisher

Oxford University Press (OUP)

Published in
Cerebral Cortex
Volume

29

Issue

4

Start page

1719

End page

1735

Subjects

Neurosciences

•

Neurosciences & Neurology

•

neuronal classification

•

neuronal morphology

•

pyramidal cells

•

rat somatosensory cortex

•

topological data analysis

•

rat visual-cortex

•

somatosensory cortex

•

calcium transients

•

action-potentials

•

neurons

•

interneurons

•

connections

•

diversity

•

representation

•

nomenclature

Note

This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
BBP-CORE  
LNMC  
Available on Infoscience
September 5, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/160846
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