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research article

Impact of organic compounds on the stability of influenza A virus in deposited 1-μL droplets

Schaub, Aline Laetitia  
•
David, Shannon Christa  
•
Glas, Irina
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August 22, 2024
mSphere

The composition of respiratory fluids influences the stability of viruses in exhaled aerosol particles and droplets, though the role of respiratory organics in modulating virus stability remains poorly understood. This study investigates the effect of organic compounds on the stability of influenza A virus (IAV) in deposited drop lets. We compare the infectivity loss of IAV at different relative humidities (RHs) over the course of 1 h in 1-µL droplets consisting of phosphate-buffered saline (without organics), synthetic lung fluid, or nasal mucus (both containing organics). We show that IAV stability increases with increasing organic:salt ratios. Among the various organic species, proteins are identified as the most protective component, with smaller proteins stabilizing IAV more efficiently at the same mass concentration. Organics act by both increasing the efflorescence RH and shortening the drying period until efflorescence at a given RH. This research advances our mechanistic understanding of how organics stabilize exhaled viruses and thus influence their inactivation in respiratory droplets.

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Type
research article
DOI
10.1128/msphere.00414-24
Author(s)
Schaub, Aline Laetitia  

EPFL

David, Shannon Christa  

EPFL

Glas, Irina
Klein, Liviana
Violaki, Kalliopi  

EPFL

Terrettaz, Céline  

EPFL

Motos, Ghislain  

EPFL

Bluvshtein, Nir
Luo, Beiping
Pohl, Marie
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Date Issued

2024-08-22

Published in
mSphere
URL

Data files

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LEV  
LAPI  
FunderFunding(s)Grant NumberGrant URL

Swiss National Science Foundation

189939

RelationRelated workURL/DOI

IsSupplementedBy

Data for: Schaub et al., Impact of Organic Compounds on the Stability of Influenza A Virus in deposited 1-µl droplets

https://zenodo.org/records/11204219
Available on Infoscience
August 23, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/240829
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