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research article

How Good are Neuron Models?

Gerstner, Wulfram  
•
Naud, Richard  
2009
Science

Opinions strongly diverge on what constitutes a good model of a neuron. Two lines of thought on this have coexisted for a long time: detailed biophysical models (of the style proposed in 1952 by the physiologists Alan Hodgkin and Andrew Huxley) that describe ion channels on the tree-like spatial structure of the neuronal cell, and simple "integrate-and-fire" models based on the much older insight that pulsatile electrical activity (known as an action potential or spike) is a threshold process. Electrophysiologists generally prefer the biophysical models, familiar with the notion of ion channels that open and close (and hence, alter neuronal activity) depending on environmental conditions. Theoreticians, by contrast, typically prefer simple neuron models with few parameters that are amenable to mathematical analysis. Earlier this year, following previous attempts at model comparison on a smaller scale, the International Neuroinformatics Coordinating Facility (INCF) launched an international competition that allowed a quantitative comparison of neuron models.

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Type
research article
DOI
10.1126/science.1181936
Web of Science ID

WOS:000270818600036

Author(s)
Gerstner, Wulfram  
Naud, Richard  
Date Issued

2009

Publisher

American Association for the Advancement of Science

Published in
Science
Volume

326

Issue

5951

Start page

379

End page

380

Subjects

Pyramidal Neurons

•

Dendrites

Note

For access to official pdf, click on the URL link BELOW

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
LCN  
Available on Infoscience
October 27, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/43892
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