Several contrasting effects are reported in the existing literature concerning the impact assessment of the COVID19 outbreak on the use of energy in buildings. Following an in-depth literature review, we here propose a GISbased approach, based on pre-pandemic, partial, and full lockdown scenarios, using a bottom-up engineering model to quantify these impacts. The model has been verified against measured energy data from a total number of 451 buildings in three urban neighborhoods in the Canton of Geneva, Switzerland. The accuracy of the engineering model in predicting the energy demand has been improved by 10%, in terms of the mean absolute percentage error, as a result of adopting a data-driven correction with a random forest algorithm. The obtained results show that the energy demand for space heating and cooling tended to increase by 8% and 17%, respectively, during the partial lockdown, while these numbers rose to 13% and 28% in the case of the full lockdown. The study also reveals that the introduced detailed occupancy scenarios are the key to improving the accuracy of urban building energy models (UBEMs). Finally, it is shown that the proposed GIS-based approach can be used to mitigate the expected impacts of any possible future pandemic in urban neighborhoods.