Iterative real-time optimization schemes that employ modifier adaptation add bias and gradient correction terms to the model that is used for optimization. These affine corrections lead to meeting the first-order necessary conditions of optimality of the plant despite plant-model mismatch. However, since the added terms do not include curvature information, satisfaction of the second-order sufficient conditions of optimality is not guaranteed, and the model might be deemed inadequate for optimization. In the context of modifier adaptation, this paper proposes to include a dedicated parameter-estimation step such that also the second-order optimality conditions are met at the plant optimum. In addition, we propose a procedure to select the best parameters to adapt based on a local sensitivity analysis. A simulation study dealing with product maximization in a fed-batch reactor demonstrates that the proposed scheme can both select the right parameters and determine their values such that modifier adaptation can drive the plant to optimality fast and without oscillations. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.