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research article

Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Fernandes, Thiago P.
•
Shaqiri, Albulena  
•
Brand, Andreas
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May 1, 2019
Psychiatry Research

Schizophrenia (SCZ) patients show deficits in many domains, including cognition and perception. However, results are often mixed. One reason for mixed results may be differences in medication. Very little is known about the role of medication in visual processing. Here, we investigated the effects of typical vs. atypical medication on contrast sensitivity (spatial frequencies ranging from 0.2 to 20 cycles per degree), vernier acuity, and visual backward masking. From a large pool of patients, we selected 50 patients (Study 1, conducted in Brazil) and 97 patients (Study 2, conducted in Georgia) taking either only typical or atypical medication. Patients with atypical medication performed significantly better than patients with typical medication for contrast sensitivity, vernier duration, and backward masking. As a secondary result, we found similar, but not significant, trends for the cognitive tasks (Stroop, Flanker, Trail-Making Test-B, Wisconsin Card Sorting Test and Continuous Performance Test) in the same patients. No correlations were found between demographics, psychopathology, chlorpromazine equivalents and visual processing. A conclusion of our study is that one needs to be careful comparing studies when medication is not comparable.

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Type
research article
DOI
10.1016/j.psychres.2019.03.008
Web of Science ID

WOS:000469156400005

Author(s)
Fernandes, Thiago P.
Shaqiri, Albulena  
Brand, Andreas
Nogueira, Renata L.
Herzog, Michael H.  
Roinishvili, Maya
Santos, Natanael A.
Chkonia, Eka
Date Issued

2019-05-01

Published in
Psychiatry Research
Volume

275

Start page

31

End page

38

Subjects

Psychiatry

•

Psychiatry

•

schizophrenia

•

visual processing

•

antipsychotics

•

contrast sensitivity

•

backward masking

•

psychopathology

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backward-masking

•

contrast sensitivity

•

sustained attention

•

deficits

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risperidone

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perception

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neuroleptics

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olanzapine

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quetiapine

•

stimuli

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LPSY  
Available on Infoscience
June 18, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/157882
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