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  4. Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes
 
research article

Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes

Aliakbari, Nima
•
De Micheli, Giovanni  
•
Carrara, Sandro  
2016
Analytical Chemistry

Unexplored electrochemical behavior of abiraterone, a recent and widely used prostate cancer drug, in interaction with cytochrome P450 3A4 (CYP3A4) enzyme and multiwalled carbon nanotubes (MWCNTs) is investigated in this work. The results reported in this work are significant for personalized medicine and point-of-care chemical treatment, especially to improve the life expectancy and quality of life of patients with prostate-cancer. To this purpose, enzymatic and nonenzymatic electrochemical biosensors were developed and characterized with different concentrations of abiraterone. Nonenzymatic biosensors were functionalized with MWCNTs as a catalyst for signal enhancement, while enzymatic biosensors have been obtained with CYP3A4 protein immobilized on MWCNTs as recognition biomolecule. Enzymatic electrochemical experiments demonstrated an inhibition effect on the CYP3A4, clearly observed as a diminished electrocatalytic activity of the enzyme. Electrochemical responses of nonenzymatic biosensors clearly demonstrated the direct electroactivity of abiraterone when reacting with MWCNT as well as an electrode-fouling effect.

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Type
research article
DOI
10.1021/acs.analchem.6b02747
Web of Science ID

WOS:000384842200003

Author(s)
Aliakbari, Nima
De Micheli, Giovanni  
Carrara, Sandro  
Date Issued

2016

Publisher

Amer Chemical Soc

Published in
Analytical Chemistry
Volume

88

Issue

19

Start page

9347

End page

9350

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSI1  
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/129617
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